Spyre Therapeutics, Inc. (SYRE)
| Market Cap | 7.97B +669.6% |
| Revenue (ttm) | n/a |
| Net Income | -150.21M |
| EPS | -2.01 |
| Shares Out | 88.17M |
| PE Ratio | n/a |
| Forward PE | n/a |
| Dividend | n/a |
| Ex-Dividend Date | n/a |
| Volume | 1,266,540 |
| Open | 91.75 |
| Previous Close | 93.62 |
| Day's Range | 89.45 - 93.39 |
| 52-Week Range | 14.51 - 110.18 |
| Beta | 3.03 |
| Analysts | Strong Buy |
| Price Target | 119.71 (+32.48%) |
| Earnings Date | Aug 4, 2026 |
About SYRE
Spyre Therapeutics, Inc., a clinical stage biotechnology company, focuses on developing therapeutics for patients living with inflammatory bowel disease (IBD) and rheumatic diseases. The company develops SPY001, a humanized monoclonal immunoglobulin G1 antibody that is in phase-2 clinical stage designed to bind selectively to the α4β7 integrin being developed for the treatment of IBD (ulcerative colitis and Crohn’s disease); and SPY002 and SPY072 – anti-TL1A mAbs designed to bind to tumor necrosis factor-like ligand 1A (TL1A). It is also develo... [Read more]
Financial Performance
Financial StatementsAnalyst Summary
According to 17 analysts, the average rating for SYRE stock is "Strong Buy." The 12-month stock price target is $119.71, which is an increase of 32.48% from the latest price.
News
Spyre Therapeutics falls -13.2%
Spyre Therapeutics (SYRE) is down -13.2%, or -$14.16 to $93.20.
Spyre Therapeutics falls -11.6%
Spyre Therapeutics (SYRE) is down -11.6%, or -$12.47 to $94.89.
Spyre Therapeutics price target lowered to $123 from $130 at Wedbush
Wedbush lowered the firm’s price target on Spyre Therapeutics (SYRE) to $123 from $130 and keeps an Outperform rating on the shares. The firm notes the company reported topline Phase…
Spyre Therapeutics price target lowered to $121 from $132 at BTIG
BTIG lowered the firm’s price target on Spyre Therapeutics (SYRE) to $121 from $132 and keeps a Buy rating on the shares. The firm cites the company’s findings on SPY072,…
Spyre Therapeutics price target lowered to $127 from $135 at Deutsche Bank
Deutsche Bank lowered the firm’s price target on Spyre Therapeutics (SYRE) to $127 from $135 and keeps a Buy rating on the shares following the topline results from the rheumatoid…
Spyre Therapeutics Stock (SYRE) Tumbles 14% in After-Hours – Here’s What Spooked Investors
Spyre Therapeutics ($SYRE) fell as much as 14% in after‑hours trading on Tuesday after the company said it will stop developing its rheumatoid arthritis (RA) drug SPY072 as a standalone…
Spyre Therapeutics announces results from RA sub-study of SKYWAY basket trial
Spyre Therapeutics (SYRE) announced results from the RA sub-study of its Phase 2 SKYWAY basket trial evaluating SPY072 in rheumatic diseases. Both doses of SPY072 demonstrated statistically significan...
Spyre Therapeutics Announces Topline Results from the Rheumatoid Arthritis Sub-study of the SKYWAY Phase 2 Trial of SPY072
Both doses of SPY072 demonstrated statistically significant benefits compared to placebo on one or more of the primary (change from baseline in DAS28-CRP), key secondary (ACR20), and exploratory endpo...
Spyre Therapeutics Announces Grants of Inducement Awards
WALTHAM, Mass., Aug. 07, 2026 (GLOBE NEWSWIRE) -- Spyre Therapeutics, Inc. (NASDAQ: SYRE) (the “Company” or “Spyre”), a clinical-stage biotechnology company committed to developing next-generation the...
Spyre Therapeutics price target raised to $130 from $100 at Wedbush
Wedbush analyst David Nierengarten raised the firm’s price target on Spyre Therapeutics (SYRE) to $130 from $100 and keeps an Outperform rating on the shares. In Q2 earnings, the company…
Spyre Therapeutics price target raised to $120 from $90 at Baird
Baird raised the firm’s price target on Spyre Therapeutics (SYRE) to $120 from $90 and keeps an Outperform rating on the shares. The firm updated its model following Q2 results…
Spyre Therapeutics price target raised to $130 from $115 at Guggenheim
Guggenheim raised the firm’s price target on Spyre Therapeutics (SYRE) to $130 from $115 and keeps a Buy rating on the shares. The firm remains “optimistic” that Spyre is “best…
Spyre Therapeutics price target raised to $115 from $90 at Wells Fargo
Wells Fargo raised the firm’s price target on Spyre Therapeutics (SYRE) to $115 from $90 and keeps an Overweight rating on the shares. The firm says positive SPY001/SPY002 data, completed…
Spyre Therapeutics reports Q2 EPS (36c), consensus (75c)
“Following encouraging Phase 2 results from both SPY001 and SPY002, as well as competitor results validating the promise of combination therapy, the case for our approach in IBD has strengthened…
Spyre Therapeutics Reports Second Quarter 2026 Financial Results and Provides Corporate Update
Announced positive topline induction data for SPY001 and SPY002 from Part A of the Phase 2 SKYLINE trial (“SKYLINE”), demonstrating best-in-class efficacy potential and a safety profile consistent wit...
Spyre Therapeutics Quarterly report: Q2 2026
Spyre Therapeutics has published its Q2 2026 quarterly earnings report on August 4, 2026.
Spyre Therapeutics Earnings release: Q2 2026
Spyre Therapeutics released its Q2 2026 earnings on August 4, 2026, summarizing the period's financial results.
Spyre Therapeutics downgraded to Peer Perform from Outperform at Wolfe Research
Wolfe Research downgraded Spyre Therapeutics (SYRE) to Peer Perform from Outperform without a price target The firm believes the shares are trading at fair value on a standalone basis. Spyre…
Spyre Therapeutics price target raised to $120 from $84 at Mizuho
Mizuho raised the firm’s price target on Spyre Therapeutics (SYRE) to $120 from $84 and keeps an Outperform rating on the shares. The firm believes the recent SKYLINE Part A…
Spyre Therapeutics files automatic mixed securities shelf
16:09 EDT Spyre Therapeutics (SYRE) files automatic mixed securities shelf
Spyre Therapeutics price target raised to $135 from $115 at Deutsche Bank
Deutsche Bank raised the firm’s price target on Spyre Therapeutics (SYRE) to $135 from $115 and keeps a Buy rating on the shares. The firm added a third inflammatory bowel…
Spyre Therapeutics price target raised to $100 from $80 at Wedbush
Wedbush raised the firm’s price target on Spyre Therapeutics (SYRE) to $100 from $80 and keeps an Outperform rating on the shares. The firm notes the company released its first…
Spyre says bowel disease drug cuts inflammation in mid-stage trial
Spyre Therapeutics said on Monday its experimental bowel disease drug met the main goal of significantly reducing disease severity in a mid-stage trial.
Spyre Announces Potential Best-in-Class SPY002 (anti-TL1A) Part A Induction Results from SKYLINE Trial in Moderate-to-Severe Ulcerative Colitis Patients
SPY002 met its primary endpoint with a statistically significant reduction of 10.7 points (p
Spyre Therapeutics Transcript: Goldman Sachs 47th Annual Global Healthcare Conference 2026
The company is advancing a pipeline of long-acting, co-formulatable antibodies for autoimmune diseases, with multiple phase II readouts expected in the next year and combination therapy data in 2027. Strategic focus includes both IBD and rheumatic diseases, leveraging unique technology to optimize efficacy and safety. Commercial launches are targeted for early next decade.