Spyre Therapeutics, Inc. (SYRE)
NASDAQ: SYRE · Real-Time Price · USD
63.27
+11.98 (23.36%)
At close: Apr 13, 2026, 4:00 PM EDT
62.29
-0.98 (-1.55%)
After-hours: Apr 13, 2026, 7:57 PM EDT
Spyre Therapeutics Analyst Ratings
Total Analysts
9
Consensus Rating
Strong Buy
Price Target
$72.78
Upside
+15.03%
Ratings History
| Analyst | Firm | Rating | Rating | Action | Price Target | Upside | Date |
|---|---|---|---|---|---|---|---|
| Leerink Partners | Leerink Partners | Buy Maintains $49 → $106 | Buy | Maintains | $49 → $106 | +67.54% | Apr 13, 2026 |
| Jefferies | Jefferies | Strong Buy Maintains $47 → $85 | Strong Buy | Maintains | $47 → $85 | +34.34% | Apr 13, 2026 |
| BTIG | BTIG | Strong Buy Maintains $70 → $98 | Strong Buy | Maintains | $70 → $98 | +54.89% | Apr 13, 2026 |
| BTIG | BTIG | Strong Buy Reiterates $70 | Strong Buy | Reiterates | $70 | +10.64% | Mar 31, 2026 |
| Stifel | Stifel | Strong Buy Maintains $70 → $92 | Strong Buy | Maintains | $70 → $92 | +45.41% | Mar 18, 2026 |
| BTIG | BTIG | Strong Buy Reiterates $70 | Strong Buy | Reiterates | $70 | +10.64% | Mar 16, 2026 |
| Wells Fargo | Wells Fargo | Buy Maintains $40 → $50 | Buy | Maintains | $40 → $50 | -20.97% | Feb 20, 2026 |
| BTIG | BTIG | Strong Buy Reiterates $70 | Strong Buy | Reiterates | $70 | +10.64% | Feb 20, 2026 |
| BTIG | BTIG | Strong Buy Reiterates $70 | Strong Buy | Reiterates | $70 | +10.64% | Jan 16, 2026 |
| Mizuho | Mizuho | Buy Initiates $53 | Buy | Initiates | $53 | -16.23% | Dec 18, 2025 |
| Citigroup | Citigroup | Strong Buy Initiates $64 | Strong Buy | Initiates | $64 | +1.15% | Dec 17, 2025 |
| Jones Trading | Jones Trading | Hold → Strong Buy Upgrades $64 | Hold → Strong Buy | Upgrades | $64 | +1.15% | Dec 1, 2025 |
| Deutsche Bank | Deutsche Bank | Strong Buy Initiates $43 | Strong Buy | Initiates | $43 | -32.04% | Sep 26, 2025 |
| BTIG | BTIG | Strong Buy Reiterates $70 | Strong Buy | Reiterates | $70 | +10.64% | Sep 16, 2025 |
| Leerink Partners | Leerink Partners | Buy Initiates $45 | Buy | Initiates | $45 | -28.88% | Apr 8, 2025 |
| Jones Trading | Jones Trading | Hold Initiates n/a | Hold | Initiates | n/a | n/a | Dec 11, 2024 |
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Analyst Star Rankings
Our analyst star rankings are based on these four factors
- Success Rate
- The percentage of ratings that are profitable.
- Average Return
- The average percentage return within one year of the rating.
- Rating Count
- The more ratings the analyst has provided, the higher the score.
- Recency
- Ratings provided within the past year contribute to a higher score.