Ionis Pharmaceuticals, Inc. (IONS)

NASDAQ: IONS · Real-Time Price · USD

41.24

-2.28 (-5.24%)

At close: Nov 2, 2026, 4:00 PM EST

41.56

+0.32 (0.78%)

After-hours: Nov 2, 2026, 7:30 PM EST

Ionis Pharmaceuticals Ratios and Metrics

Market cap in millions USD. Fiscal year is January - December.

Millions USD. Fiscal year is Jan - Dec.

Total Valuation

Fiscal Year	Current	FY 2025	FY 2024	FY 2023	FY 2022	FY 2021
Period Ending	Nov '26 Nov 2, 2026	Dec '25 Dec 31, 2025	Dec '24 Dec 31, 2024	Dec '23 Dec 31, 2023	Dec '22 Dec 31, 2022	Dec '21 Dec 31, 2021
Market Capitalization	6,853	12,814	5,520	7,258	5,365	4,297
Market Cap Growth	-41.14%	132.13%	-23.95%	35.28%	24.86%	-45.65%
Enterprise Value	6,940	12,619	5,024	6,991	4,631	3,606
Last Close Price	41.24	79.11	34.96	50.59	37.77	30.43

Fiscal Year	Current	FY 2025	FY 2024	FY 2023	FY 2022	FY 2021
Period Ending	Nov '26 Nov 2, 2026	Dec '25 Dec 31, 2025	Dec '24 Dec 31, 2024	Dec '23 Dec 31, 2023	Dec '22 Dec 31, 2022	Dec '21 Dec 31, 2021
Forward PE	-	216.04	216.04	216.04	216.04	216.04
PS Ratio	7.84	13.58	7.83	9.22	9.13	5.30
PB Ratio	15.53	26.20	9.38	18.77	9.37	5.57
P/TBV Ratio	15.59	26.20	9.38	18.77	9.37	5.57
P/FCF Ratio	-	-	-	-	-	228.03
P/OCF Ratio	-	-	-	-	-	139.52
PEG Ratio	-	281.03	281.03	281.03	281.03	281.03

Fiscal Year	Current	FY 2025	FY 2024	FY 2023	FY 2022	FY 2021
Period Ending	Nov '26 Nov 2, 2026	Dec '25 Dec 31, 2025	Dec '24 Dec 31, 2024	Dec '23 Dec 31, 2023	Dec '22 Dec 31, 2022	Dec '21 Dec 31, 2021
EV/Sales Ratio	7.94	13.37	7.13	8.88	7.88	4.45
EV/FCF Ratio	-	-	-	-	-	191.38

Fiscal Year	Current	FY 2025	FY 2024	FY 2023	FY 2022	FY 2021
Period Ending	Nov '26 Nov 2, 2026	Dec '25 Dec 31, 2025	Dec '24 Dec 31, 2024	Dec '23 Dec 31, 2023	Dec '22 Dec 31, 2022	Dec '21 Dec 31, 2021
Debt / Equity Ratio	4.98	5.35	3.33	5.09	2.39	1.62
Debt / FCF Ratio	-	-	-	-	-	66.39
Net Debt / Equity Ratio	0.20	-0.13	-0.58	-0.96	-1.10	-1.14
Net Debt / EBITDA Ratio	-0.15	0.18	0.74	1.09	1.60	71.44
Net Debt / FCF Ratio	-0.15	0.20	0.63	1.12	2.17	-46.81
Asset Turnover	0.29	0.29	0.24	0.28	0.23	0.32
Inventory Turnover	31.52	82.58	91.49	61.67	36.18	27.98
Quick Ratio	6.85	3.51	7.74	5.44	6.49	9.13
Current Ratio	7.89	3.83	8.47	5.90	7.07	9.75
Return on Equity (ROE)	-105.50%	-70.80%	-93.10%	-76.34%	-40.12%	-3.77%
Return on Assets (ROA)	-12.42%	-7.31%	-9.91%	-8.00%	-9.96%	-0.75%
Return on Invested Capital (ROIC)	-72.02%	-114.15%	-194.54%	-	-	-
Return on Capital Employed (ROCE)	-22.20%	-13.90%	-17.60%	-13.90%	-18.50%	-1.30%

Fiscal Year	Current	FY 2025	FY 2024	FY 2023	FY 2022	FY 2021
Period Ending	Nov '26 Nov 2, 2026	Dec '25 Dec 31, 2025	Dec '24 Dec 31, 2024	Dec '23 Dec 31, 2023	Dec '22 Dec 31, 2022	Dec '21 Dec 31, 2021
Earnings Yield	-8.40%	-2.98%	-8.22%	-5.05%	-5.03%	-0.67%
FCF Yield	-8.18%	-2.50%	-9.89%	-4.57%	-5.41%	0.44%
Buyback Yield / Dilution	-4.49%	-7.02%	-4.42%	-0.95%	-0.59%	-1.01%

SEC Filings: 10-K · 10-Q