Ionis Pharmaceuticals Ratios and Metrics

Market cap in millions USD. Fiscal year is January - December.

Millions USD. Fiscal year is Jan - Dec.

Fiscal Year	Current	FY 2025	FY 2024	FY 2023	FY 2022	FY 2021
Period Ending	Jul '26 Jul 23, 2026	Dec '25 Dec 31, 2025	Dec '24 Dec 31, 2024	Dec '23 Dec 31, 2023	Dec '22 Dec 31, 2022	Dec '21 Dec 31, 2021
Market Cap	8,899	12,919	5,520	7,302	5,366	4,297
Market Cap Growth	33.90%	134.02%	-24.40%	36.09%	24.87%	-45.86%
Enterprise Value	9,558	12,283	4,630	6,416	4,740	3,430
Last Close Price	53.85	79.11	34.96	50.59	37.77	30.43
Forward PE	-	216.04	216.04	216.04	216.04	216.04
PEG Ratio	-	281.03	281.03	281.03	281.03	281.03
PS Ratio	8.44	13.69	7.83	9.27	9.13	5.30
PB Ratio	18.23	26.41	9.38	18.89	9.37	5.57
P/TBV Ratio	18.33	25.88	8.88	18.74	9.35	5.56
P/FCF Ratio	-	-	-	-	-	228.03
P/OCF Ratio	-	-	-	-	-	139.52
EV/Sales Ratio	9.03	13.02	6.57	8.15	8.07	4.23
EV/FCF Ratio	-	-	-	-	-	182.00
Debt / Equity Ratio	3.27	3.29	2.39	3.62	2.38	1.62
Debt / EBITDA Ratio	12.40	-	-	-	-	-
Debt / FCF Ratio	-	-	-	-	-	66.20
Net Debt / Equity Ratio	0.25	-1.30	-1.51	-2.29	-1.09	-1.12
Net Debt / EBITDA Ratio	0.74	1.77	1.97	2.68	1.61	81.64
Net Debt / FCF Ratio	-0.12	1.99	1.63	2.68	2.15	-46.03
Asset Turnover	0.30	0.29	0.24	0.29	0.23	0.32
Inventory Turnover	2.23	1.41	1.12	0.62	0.60	0.46
Quick Ratio	2.78	3.51	7.73	5.42	6.46	9.05
Current Ratio	4.10	3.83	8.47	5.90	7.07	9.75
Return on Equity (ROE)	25.20%	-70.80%	-93.10%	-76.34%	-40.12%	-3.78%
Return on Assets (ROA)	3.98%	-11.75%	-15.64%	-14.05%	-16.67%	-1.18%
Return on Capital Employed (ROCE)	5.11%	-14.04%	-18.15%	-14.85%	-17.86%	-1.45%
FCF Yield	-	-	-	-	-	0.44%
Buyback Yield / Dilution	-5.71%	-7.02%	-4.42%	-0.95%	-0.59%	-1.01%
Total Shareholder Return	-5.71%	-7.02%	-4.42%	-0.95%	-0.59%	-1.01%

SEC Filings: 10-K · 10-Q