Ionis Pharmaceuticals, Inc. (IONS)

Ionis Pharmaceuticals Ratios and Metrics

Market cap in millions USD. Fiscal year is January - December.

Fiscal Year	Current	FY 2024	FY 2023	FY 2022	FY 2021	FY 2020
Period Ending	Feb 13, 2026	Dec 31, 2024	Dec 31, 2023	Dec 31, 2022	Dec 31, 2021	Dec 31, 2020
Market Capitalization	13,055	5,520	7,258	5,365	4,297	7,906
Market Cap Growth	148.14%	-23.95%	35.28%	24.86%	-45.65%	-6.97%
Enterprise Value	12,871	5,024	6,991	4,631	3,606	6,615
Last Close Price	80.60	34.96	50.59	37.77	30.43	56.54
PS Ratio	13.24	7.83	9.22	9.13	5.30	10.84
PB Ratio	21.02	9.38	18.77	9.37	5.57	10.64
P/TBV Ratio	21.13	9.38	18.77	9.37	5.57	11.05
P/FCF Ratio	-	-	-	-	228.03	10240.42
P/OCF Ratio	-	-	-	-	139.52	220.26
EV/Sales Ratio	13.31	7.13	8.88	7.88	4.45	9.07
EV/FCF Ratio	-	-	-	-	191.38	8569.00
Debt / Equity Ratio	3.33	3.33	5.09	2.39	1.62	1.26
Debt / FCF Ratio	-	-	-	-	66.39	1217.15
Net Debt / Equity Ratio	-0.30	-0.58	-0.96	-1.10	-1.14	-1.29
Net Debt / EBITDA Ratio	0.69	0.74	1.15	1.60	71.44	6.13
Net Debt / FCF Ratio	0.61	0.63	1.12	2.17	-46.81	-1242.85
Asset Turnover	0.32	0.24	0.28	0.23	0.32	0.26
Inventory Turnover	45.90	91.49	61.67	36.18	27.98	0.60
Quick Ratio	2.51	7.74	5.44	6.49	9.13	3.30
Current Ratio	2.79	8.47	5.90	7.07	9.75	3.56
Return on Equity (ROE)	-40.04%	-93.10%	-76.34%	-40.12%	-3.77%	-39.52%
Return on Assets (ROA)	-5.68%	-9.91%	-7.55%	-9.96%	-0.75%	-3.82%
Return on Invested Capital (ROIC)	-73.48%	-364.50%	-	-	-	-
Return on Capital Employed (ROCE)	-13.10%	-17.60%	-13.10%	-18.50%	-1.30%	-9.60%
Earnings Yield	-1.96%	-8.22%	-5.05%	-5.03%	-0.67%	-5.62%
FCF Yield	-2.32%	-9.89%	-4.57%	-5.41%	0.44%	0.01%
Buyback Yield / Dilution	-8.89%	-4.42%	-0.95%	-0.59%	-1.01%	8.85%

Updated Oct 29, 2025. Source: S&P Global Market Intelligence. Standard template. Financial Sources.

SEC Filings: 10-K · 10-Q