Ionis Pharmaceuticals, Inc. (IONS)

Ionis Pharmaceuticals Ratios and Metrics

Market cap in millions USD. Fiscal year is January - December.

Year Ending	Current	Dec 31, 2023	Dec 31, 2022	Dec 31, 2021	Dec 31, 2020	Dec 31, 2019
Market Capitalization	6,980	7,258	5,365	4,297	7,906	8,497
Market Cap Growth	23.67%	35.28%	24.86%	-45.65%	-6.97%	14.26%
Enterprise Value	6,218	6,372	4,740	3,430	6,953	6,785
PE Ratio	-	-19.82	-19.89	-150.26	-17.80	30.55
PS Ratio	8.99	9.22	9.13	5.30	10.84	7.57
PB Ratio	23.54	18.77	9.37	5.57	10.64	5.78
P/FCF Ratio	-18.51	-21.91	-149.00	228.03	10240.41	27.00
P/OCF Ratio	-19.53	-23.60	-19.55	139.52	220.26	24.59
EV/Sales Ratio	8.01	8.09	8.07	4.23	9.53	6.04
EV/EBITDA Ratio	-21.81	-27.70	-20.81	-14349.67	-96.03	19.05
EV/EBIT Ratio	-20.04	-25.23	-18.97	-173.22	-77.63	19.84
EV/FCF Ratio	-16.28	-19.23	-131.64	182.00	9006.30	21.56
Debt / Equity Ratio	4.87	3.74	2.38	1.62	1.26	0.54
Debt / EBITDA Ratio	-5.67	-6.28	-5.98	-5219.77	-12.98	2.21
Debt / FCF Ratio	-4.23	-4.36	-37.82	66.20	1217.15	2.50
Quick Ratio	6.75	5.42	6.46	9.05	3.29	9.39
Current Ratio	7.37	5.90	7.07	9.75	3.56	9.97
Asset Turnover	0.27	0.27	0.24	0.33	0.25	0.38
Interest Coverage	-3.21	-3.10	-30.76	-2.12	-9.42	27.50
Return on Equity (ROE)	-107.90%	-90.60%	-43.10%	-4.50%	-36.50%	21.10%
Return on Assets (ROA)	-13.20%	-12.40%	-10.90%	-1.20%	-15.20%	9.40%
Return on Capital (ROIC)	-22.36%	-19.31%	-21.20%	-1.49%	-10.23%	13.67%
Earnings Yield	-5.51%	-5.05%	-5.03%	-0.67%	-5.62%	3.27%
FCF Yield	-4.89%	-4.56%	-0.67%	0.44%	0.01%	3.70%
Buyback Yield / Dilution	-1.96%	-0.95%	-0.59%	-1.01%	8.85%	-14.25%
Total Shareholder Return	-1.96%	-0.95%	-0.59%	-1.01%	8.85%	-14.25%

Source: Financials are provided by Nasdaq Data Link and sourced from the audited annual (10-K) and quarterly (10-Q) reports submitted to the Securities and Exchange Commission (SEC).