Ionis Pharmaceuticals, Inc. (IONS)

Ionis Pharmaceuticals Ratios and Metrics

Market cap in millions USD. Fiscal year is January - December.

Fiscal Year	Current	FY 2025	FY 2024	FY 2023	FY 2022	FY 2021
Period Ending	Mar 3, 2026	Dec 31, 2025	Dec 31, 2024	Dec 31, 2023	Dec 31, 2022	Dec 31, 2021
Market Capitalization	12,994	12,814	5,520	7,258	5,365	4,297
Market Cap Growth	171.15%	132.13%	-23.95%	35.28%	24.86%	-45.65%
Enterprise Value	12,995	12,619	5,024	6,991	4,631	3,606
Last Close Price	81.96	79.11	34.96	50.59	37.77	30.43
PS Ratio	13.84	13.58	7.83	9.22	9.13	5.30
PB Ratio	27.37	26.20	9.38	18.77	9.37	5.57
P/TBV Ratio	26.70	26.20	9.38	18.77	9.37	5.57
P/FCF Ratio	-	-	-	-	-	228.03
P/OCF Ratio	-	-	-	-	-	139.52
EV/Sales Ratio	13.77	13.37	7.13	8.88	7.88	4.45
EV/FCF Ratio	-	-	-	-	-	191.38
Debt / Equity Ratio	5.35	5.35	3.33	5.09	2.39	1.62
Debt / FCF Ratio	-	-	-	-	-	66.39
Net Debt / Equity Ratio	-0.13	-0.13	-0.58	-0.96	-1.10	-1.14
Net Debt / EBITDA Ratio	0.18	0.18	0.74	1.09	1.60	71.44
Net Debt / FCF Ratio	0.20	0.20	0.63	1.12	2.17	-46.81
Asset Turnover	0.29	0.29	0.24	0.28	0.23	0.32
Inventory Turnover	82.58	82.58	91.49	61.67	36.18	27.98
Quick Ratio	3.51	3.51	7.74	5.44	6.49	9.13
Current Ratio	3.83	3.83	8.47	5.90	7.07	9.75
Return on Equity (ROE)	-70.80%	-70.80%	-93.10%	-76.34%	-40.12%	-3.77%
Return on Assets (ROA)	-7.31%	-7.31%	-9.91%	-8.00%	-9.96%	-0.75%
Return on Invested Capital (ROIC)	-90.05%	-114.15%	-364.50%	-	-	-
Return on Capital Employed (ROCE)	-13.90%	-13.90%	-17.60%	-13.90%	-18.50%	-1.30%
Earnings Yield	-2.92%	-2.98%	-8.22%	-5.05%	-5.03%	-0.67%
FCF Yield	-2.45%	-2.50%	-9.89%	-4.57%	-5.41%	0.44%
Buyback Yield / Dilution	-7.02%	-7.02%	-4.42%	-0.95%	-0.59%	-1.01%

Updated Feb 25, 2026. Source: S&P Global Market Intelligence. Standard template. Financial Sources.

SEC Filings: 10-K · 10-Q