Ionis Pharmaceuticals, Inc. (IONS)

Ionis Pharmaceuticals Ratios and Metrics

Market cap in millions USD. Fiscal year is January - December.

Fiscal Year	Current	FY 2024	FY 2023	FY 2022	FY 2021	FY 2020
Period Ending	Oct 31, 2025	Dec 31, 2024	Dec 31, 2023	Dec 31, 2022	Dec 31, 2021	Dec 31, 2020
Market Capitalization	12,035	5,520	7,258	5,365	4,297	7,906
Market Cap Growth	110.19%	-23.95%	35.28%	24.86%	-45.65%	-6.97%
Enterprise Value	11,851	5,024	6,991	4,631	3,606	6,615
Last Close Price	74.30	34.96	50.59	37.77	30.43	56.54
PS Ratio	12.21	7.83	9.22	9.13	5.30	10.84
PB Ratio	19.37	9.38	18.77	9.37	5.57	10.64
P/TBV Ratio	19.47	9.38	18.77	9.37	5.57	11.05
P/FCF Ratio	-	-	-	-	228.03	10240.42
P/OCF Ratio	-	-	-	-	139.52	220.26
EV/Sales Ratio	12.26	7.13	8.88	7.88	4.45	9.07
EV/FCF Ratio	-	-	-	-	191.38	8569.00
Debt / Equity Ratio	3.33	3.33	5.09	2.39	1.62	1.26
Debt / FCF Ratio	-	-	-	-	66.39	1217.15
Asset Turnover	0.32	0.24	0.28	0.23	0.32	0.26
Inventory Turnover	45.90	91.49	61.67	36.18	27.98	0.60
Quick Ratio	2.51	7.74	5.44	6.49	9.13	3.30
Current Ratio	2.79	8.47	5.90	7.07	9.75	3.56
Return on Equity (ROE)	-40.04%	-93.10%	-76.34%	-40.12%	-3.77%	-39.52%
Return on Assets (ROA)	-5.68%	-9.91%	-7.55%	-9.96%	-0.75%	-3.82%
Return on Capital (ROIC)	-6.51%	-12.12%	-9.71%	-12.93%	-1.02%	-5.18%
Earnings Yield	-2.13%	-8.22%	-5.05%	-5.03%	-0.67%	-5.62%
FCF Yield	-2.51%	-9.89%	-4.57%	-5.41%	0.44%	0.01%
Buyback Yield / Dilution	-8.89%	-4.42%	-0.95%	-0.59%	-1.01%	8.85%

Updated Oct 29, 2025. Source: S&P Global Market Intelligence. Standard template. Financial Sources.

SEC Filings: 10-K · 10-Q