Ionis Pharmaceuticals Ratios and Metrics

Market cap in millions USD. Fiscal year is January - December.

Millions USD. Fiscal year is Jan - Dec.

Fiscal Year	Current	FY 2025	FY 2024	FY 2023	FY 2022	FY 2021
Period Ending	Mar '26 Mar 24, 2026	Dec '25 Dec 31, 2025	Dec '24 Dec 31, 2024	Dec '23 Dec 31, 2023	Dec '22 Dec 31, 2022	Dec '21 Dec 31, 2021
Market Cap	11,463	12,919	5,520	7,302	5,366	4,297
Market Cap Growth	109.68%	134.02%	-24.40%	36.09%	24.87%	-45.86%
Enterprise Value	11,629	11,851	4,630	6,371	4,740	3,430
Last Close Price	69.39	79.11	34.96	50.59	37.77	30.43
PE Ratio	-	-33.24	-11.50	-19.76	-19.88	-152.15
PS Ratio	12.39	13.69	7.83	9.27	9.13	5.30
PB Ratio	23.64	26.41	9.38	18.89	9.37	5.57
P/TBV Ratio	22.70	25.88	8.88	18.74	9.35	5.56
P/FCF Ratio	-	-40.37	-10.11	-22.04	-18.50	228.03
P/OCF Ratio	-	-48.10	-11.02	-23.75	-19.56	139.52
EV/Sales Ratio	12.32	12.56	6.57	8.09	8.07	4.23
EV/EBITDA Ratio	-	-33.01	-10.22	-19.24	-12.21	-322.75
EV/EBIT Ratio	-	-31.05	-9.75	-18.01	-11.56	-113.61
EV/FCF Ratio	-	-37.03	-8.48	-19.23	-16.34	182.00
Debt / Equity Ratio	3.29	3.29	2.39	3.62	2.38	1.62
Debt / EBITDA Ratio	-9.32	-5.69	-3.11	-4.36	-3.51	-117.40
Debt / FCF Ratio	-6.38	-6.38	-2.58	-4.36	-4.69	66.20
Net Debt / Equity Ratio	-1.30	-1.30	-1.51	-2.29	-1.09	-1.12
Net Debt / EBITDA Ratio	2.90	1.77	1.97	2.68	1.61	81.64
Net Debt / FCF Ratio	1.99	1.99	1.63	2.68	2.15	-46.03
Asset Turnover	0.29	0.29	0.24	0.29	0.23	0.32
Inventory Turnover	1.41	1.41	1.12	0.62	0.60	0.46
Quick Ratio	3.51	3.51	7.73	5.42	6.46	9.05
Current Ratio	3.83	3.83	8.47	5.90	7.07	9.75
Return on Equity (ROE)	-47.86%	-70.80%	-93.10%	-76.34%	-40.12%	-3.78%
Return on Assets (ROA)	-7.45%	-11.75%	-15.64%	-14.05%	-16.67%	-1.18%
Return on Invested Capital (ROIC)	-44.96%	-70.95%	-103.90%	-102.50%	-123.01%	-8.69%
Return on Capital Employed (ROCE)	-8.90%	-14.04%	-18.15%	-14.85%	-17.86%	-1.45%
Earnings Yield	-3.26%	-3.01%	-8.70%	-5.06%	-5.03%	-0.66%
FCF Yield	-2.74%	-2.48%	-9.89%	-4.54%	-5.41%	0.44%
Buyback Yield / Dilution	-1.49%	-1.49%	-9.47%	-0.68%	0.83%	0.12%

Updated Feb 25, 2026. Data Source: Fiscal.ai. Standard template. Financial Sources.

SEC Filings: 10-K · 10-Q