Ionis Pharmaceuticals, Inc. (IONS)

Ionis Pharmaceuticals Ratios and Metrics

Market cap in millions USD. Fiscal year is January - December.

Fiscal Year	Current	FY 2024	FY 2023	FY 2022	FY 2021	FY 2020
Period Ending	Oct 10, 2025	Dec 31, 2024	Dec 31, 2023	Dec 31, 2022	Dec 31, 2021	Dec 31, 2020
Market Cap	11,153	5,520	7,302	5,366	4,297	7,936
Market Cap Growth	86.09%	-24.40%	36.09%	24.87%	-45.86%	-6.39%
Enterprise Value	10,844	4,578	6,330	4,724	3,423	6,644
Last Close Price	69.97	34.96	50.59	37.77	30.43	56.54
PE Ratio	-	-11.50	-19.76	-19.88	-152.15	-17.78
PS Ratio	11.57	7.83	9.27	9.13	5.30	10.88
PB Ratio	17.63	9.38	18.88	9.37	5.57	10.68
P/TBV Ratio	17.93	8.88	18.73	9.35	5.56	10.62
P/FCF Ratio	-	-10.11	-22.04	-18.50	228.03	10280.14
P/OCF Ratio	-	-11.02	-23.75	-19.56	139.52	221.12
EV/Sales Ratio	11.49	6.49	8.04	8.04	4.22	9.11
EV/EBITDA Ratio	-	-10.10	-19.11	-12.17	-322.10	-42.89
EV/EBIT Ratio	-	-9.64	-17.89	-11.52	-113.38	-38.61
EV/FCF Ratio	-	-8.38	-19.10	-16.29	181.63	8606.24
Debt / Equity Ratio	1.16	2.30	3.51	2.35	1.61	0.81
Debt / EBITDA Ratio	-5.56	-2.99	-4.24	-3.47	-116.75	-5.91
Debt / FCF Ratio	-4.69	-2.48	-4.23	-4.64	65.83	1186.83
Asset Turnover	0.32	0.24	0.29	0.23	0.32	0.26
Inventory Turnover	1.00	1.12	0.62	0.60	0.46	0.60
Quick Ratio	2.61	7.73	5.42	6.46	9.05	3.29
Current Ratio	2.87	8.47	5.90	7.07	9.75	3.56
Return on Equity (ROE)	-46.17%	-95.64%	-62.87%	-36.63%	-3.92%	17.35%
Return on Assets (ROA)	-9.10%	-16.07%	-11.57%	-15.22%	-1.23%	9.58%
Return on Capital (ROIC)	-33.61%	-92.62%	-64.53%	-97.46%	-5.84%	39.90%
Return on Capital Employed (ROCE)	-11.15%	-18.15%	-14.85%	-17.86%	-1.45%	-7.24%
Earnings Yield	-2.40%	-8.70%	-5.06%	-5.03%	-0.66%	-5.62%
FCF Yield	-2.60%	-9.89%	-4.54%	-5.41%	0.44%	0.01%
Buyback Yield / Dilution	-0.17%	-9.47%	-0.67%	0.83%	0.12%	0.65%
Total Shareholder Return	-	-9.47%	-0.67%	0.83%	0.12%	0.65%

Updated Jul 30, 2025. Data Source: Fiscal.ai. Standard template. Financial Sources.

SEC Filings: 10-K · 10-Q