Ionis Pharmaceuticals Ratios and Metrics

Market cap in millions USD. Fiscal year is January - December.

Millions USD. Fiscal year is Jan - Dec.

Fiscal Year	Current	FY 2024	FY 2023	FY 2022	FY 2021	FY 2020
Period Ending	Feb '26 Feb 6, 2026	Dec '24 Dec 31, 2024	Dec '23 Dec 31, 2023	Dec '22 Dec 31, 2022	Dec '21 Dec 31, 2021	Dec '20 Dec 31, 2020
Market Capitalization	14,011	5,520	7,258	5,365	4,297	7,906
Market Cap Growth	157.50%	-23.95%	35.28%	24.86%	-45.65%	-6.97%
Enterprise Value	13,827	5,024	6,991	4,631	3,606	6,615
Last Close Price	86.50	34.96	50.59	37.77	30.43	56.54
PS Ratio	14.21	7.83	9.22	9.13	5.30	10.84
PB Ratio	22.56	9.38	18.77	9.37	5.57	10.64
P/TBV Ratio	22.67	9.38	18.77	9.37	5.57	11.05
P/FCF Ratio	-	-	-	-	228.03	10240.42
P/OCF Ratio	-	-	-	-	139.52	220.26
EV/Sales Ratio	14.30	7.13	8.88	7.88	4.45	9.07
EV/FCF Ratio	-	-	-	-	191.38	8569.00
Debt / Equity Ratio	3.33	3.33	5.09	2.39	1.62	1.26
Debt / FCF Ratio	-	-	-	-	66.39	1217.15
Asset Turnover	0.32	0.24	0.28	0.23	0.32	0.26
Inventory Turnover	45.90	91.49	61.67	36.18	27.98	0.60
Quick Ratio	2.51	7.74	5.44	6.49	9.13	3.30
Current Ratio	2.79	8.47	5.90	7.07	9.75	3.56
Return on Equity (ROE)	-40.04%	-93.10%	-76.34%	-40.12%	-3.77%	-39.52%
Return on Assets (ROA)	-5.68%	-9.91%	-7.55%	-9.96%	-0.75%	-3.82%
Return on Invested Capital (ROIC)	-73.48%	-364.50%	-	-	-	-
Return on Capital Employed (ROCE)	-13.10%	-17.60%	-13.10%	-18.50%	-1.30%	-9.60%
Earnings Yield	-1.83%	-8.22%	-5.05%	-5.03%	-0.67%	-5.62%
FCF Yield	-2.16%	-9.89%	-4.57%	-5.41%	0.44%	0.01%
Buyback Yield / Dilution	-8.89%	-4.42%	-0.95%	-0.59%	-1.01%	8.85%

Updated Oct 29, 2025. Source: S&P Global Market Intelligence. Standard template. Financial Sources.

SEC Filings: 10-K · 10-Q