Ionis Pharmaceuticals Ratios and Metrics

Market cap in millions USD. Fiscal year is January - December.

Millions USD. Fiscal year is Jan - Dec.

Fiscal Year	Current	FY 2025	FY 2024	FY 2023	FY 2022	FY 2021
Period Ending	Apr '26 Apr 13, 2026	Dec '25 Dec 31, 2025	Dec '24 Dec 31, 2024	Dec '23 Dec 31, 2023	Dec '22 Dec 31, 2022	Dec '21 Dec 31, 2021
Market Cap	12,406	12,919	5,520	7,302	5,366	4,297
Market Cap Growth	147.83%	134.02%	-24.40%	36.09%	24.87%	-45.86%
Enterprise Value	12,497	11,851	4,630	6,371	4,740	3,430
Last Close Price	75.10	79.11	34.96	50.59	37.77	30.43
PE Ratio	-	-33.24	-11.50	-19.76	-19.88	-152.15
PS Ratio	13.31	13.69	7.83	9.27	9.13	5.30
PB Ratio	25.10	26.41	9.38	18.89	9.37	5.57
P/TBV Ratio	25.45	25.88	8.88	18.74	9.35	5.56
P/FCF Ratio	-	-40.37	-10.11	-22.04	-18.50	228.03
P/OCF Ratio	-	-48.10	-11.02	-23.75	-19.56	139.52
EV/Sales Ratio	13.24	12.56	6.57	8.09	8.07	4.23
EV/EBITDA Ratio	-	-33.01	-10.22	-19.24	-12.21	-322.75
EV/EBIT Ratio	-	-31.05	-9.75	-18.01	-11.56	-113.61
EV/FCF Ratio	-	-37.03	-8.48	-19.23	-16.34	182.00
Debt / Equity Ratio	3.29	3.29	2.39	3.62	2.38	1.62
Debt / EBITDA Ratio	-5.69	-5.69	-3.11	-4.36	-3.51	-117.40
Debt / FCF Ratio	-6.38	-6.38	-2.58	-4.36	-4.69	66.20
Net Debt / Equity Ratio	-1.30	-1.30	-1.51	-2.29	-1.09	-1.12
Net Debt / EBITDA Ratio	1.77	1.77	1.97	2.68	1.61	81.64
Net Debt / FCF Ratio	1.99	1.99	1.63	2.68	2.15	-46.03
Asset Turnover	0.29	0.29	0.24	0.29	0.23	0.32
Inventory Turnover	1.41	1.41	1.12	0.62	0.60	0.46
Quick Ratio	3.51	3.51	7.73	5.42	6.46	9.05
Current Ratio	3.83	3.83	8.47	5.90	7.07	9.75
Return on Equity (ROE)	-70.80%	-70.80%	-93.10%	-76.34%	-40.12%	-3.78%
Return on Assets (ROA)	-11.75%	-11.75%	-15.64%	-14.05%	-16.67%	-1.18%
Return on Invested Capital (ROIC)	-70.95%	-70.95%	-103.90%	-102.50%	-123.01%	-8.69%
Return on Capital Employed (ROCE)	-14.04%	-14.04%	-18.15%	-14.85%	-17.86%	-1.45%
Earnings Yield	-3.04%	-3.01%	-8.70%	-5.06%	-5.03%	-0.66%
FCF Yield	-2.55%	-2.48%	-9.89%	-4.54%	-5.41%	0.44%
Buyback Yield / Dilution	-7.02%	-7.02%	-4.42%	-0.95%	-0.59%	-1.01%
Total Shareholder Return	-7.02%	-7.02%	-4.42%	-0.95%	-0.59%	-1.01%

Updated Feb 25, 2026. Data Source: Fiscal.ai. Standard template. Financial Sources.

SEC Filings: 10-K · 10-Q