Spyre Therapeutics, Inc. (SYRE)

Spyre Therapeutics Cash Flow Statement

Financials in millions USD. Fiscal year is January - December.

Fiscal Year	FY 2025	FY 2024	FY 2023	FY 2022	FY 2021
Period Ending	Dec 31, 2025	Dec 31, 2024	Dec 31, 2023	Dec 31, 2022	Dec 31, 2021
Net Income	-155.2	-208.02	-338.79	-83.82	-65.8
Depreciation & Amortization	-	-	0.96	1.96	2
Loss (Gain) From Sale of Assets	-10	-	-15.53	-	-
Asset Writedown & Restructuring Costs	-	-	132.77	-	-
Loss (Gain) From Sale of Investments	-8.09	-11.4	-2.32	-0.33	0.55
Stock-Based Compensation	37.61	44.83	25.68	7.11	8.04
Other Operating Activities	-27.64	21.71	102.53	0.43	-0.34
Change in Accounts Receivable	-	-	0.38	0.44	-0.82
Change in Accounts Payable	7.65	-16.21	-2.18	-2.64	1.07
Change in Unearned Revenue	-	-	0.58	-0.88	3.58
Change in Other Net Operating Assets	-13.58	11.68	-3.97	-2.42	-1.99
Operating Cash Flow	-169.25	-157.41	-99.91	-80.14	-53.72
Capital Expenditures	-	-	-	-0.04	-0.57
Sale of Property, Plant & Equipment	-	-	0.48	-	-
Cash Acquisitions	-	-	3.04	-	-
Sale (Purchase) of Intangibles	7	-	15	-	-
Investment in Securities	-150.48	-353.29	-126.9	57.05	-22.05
Investing Cash Flow	-143.48	-353.29	-108.39	57.01	-22.62
Long-Term Debt Repaid	-	-	-	-0.42	-0.51
Net Debt Issued (Repaid)	-	-	-	-0.42	-0.51
Issuance of Common Stock	314.44	243.89	84.96	43.1	1.9
Other Financing Activities	-5.41	-1.84	-5.8	-	-
Financing Cash Flow	309.03	410.91	361.08	42.68	1.39
Foreign Exchange Rate Adjustments	-	-0	0.03	-0.11	-0.02
Net Cash Flow	-3.7	-99.79	152.8	19.44	-74.96
Free Cash Flow	-169.25	-157.41	-99.91	-80.18	-54.29
Free Cash Flow Margin	-	-	-11276.52%	-3442.76%	-289.71%
Free Cash Flow Per Share	-2.64	-3.35	-14.49	-23.78	-20.64
Levered Free Cash Flow	-103.85	-66.57	-9.61	-50.01	-30.62
Unlevered Free Cash Flow	-103.85	-66.57	-9.61	-50.01	-30.62
Change in Working Capital	-5.93	-4.53	-5.21	-5.5	1.83

Updated Dec 31, 2025. Source: S&P Global Market Intelligence. Standard template. Financial Sources.

SEC Filings: 10-K · 10-Q