Spyre Therapeutics, Inc. (SYRE)

NASDAQ: SYRE · Real-Time Price · USD

74.05

-0.27 (-0.36%)

At close: May 22, 2026, 4:00 PM EDT

74.05

0.00 (0.00%)

After-hours: May 22, 2026, 4:10 PM EDT

Spyre Therapeutics Ratios and Metrics

Market cap in millions USD. Fiscal year is January - December.

Millions USD. Fiscal year is Jan - Dec.

Fiscal Year	Current	FY 2025	FY 2024	FY 2023	FY 2022	FY 2021
Period Ending	May '26 May 22, 2026	Dec '25 Dec 31, 2025	Dec '24 Dec 31, 2024	Dec '23 Dec 31, 2023	Dec '22 Dec 31, 2022	Dec '21 Dec 31, 2021
Market Cap	6,431	3,037	1,403	776	29	234
Market Cap Growth	752.86%	116.48%	80.78%	2538.59%	-87.46%	-37.89%
Enterprise Value	5,724	2,436	955.52	706.15	-22.3	145.92
Last Close Price	74.05	32.76	23.28	21.52	11.25	118.75
PB Ratio	11.38	4.25	2.71	4.22	0.58	2.79
P/TBV Ratio	9.52	2.93	2.11	0.81	0.75	3.72
EV/EBITDA Ratio	-	-	-	-	0.27	-
EV/EBIT Ratio	-	-	-	-	0.26	-
EV/FCF Ratio	-	-	-	-	0.28	-
Debt / Equity Ratio	-	0	0	0	0.08	0.05
Net Debt / Equity Ratio	-1.10	-1.06	-1.16	-1.84	-1.01	-1.05
Net Debt / EBITDA Ratio	3.68	3.61	2.89	1.41	0.61	1.38
Net Debt / FCF Ratio	3.99	4.47	3.83	3.40	0.64	1.62
Quick Ratio	8.71	12.89	11.16	10.61	3.83	4.66
Current Ratio	8.97	13.25	11.26	10.68	4.25	4.91
Return on Equity (ROE)	-25.89%	-25.17%	-59.28%	-289.17%	-124.87%	-58.81%
Return on Assets (ROA)	-26.16%	-30.24%	-43.88%	-117.35%	-93.80%	-48.25%
Return on Invested Capital (ROIC)	1495.32%	1115.27%	1212.19%	5099.90%	-12415.00%	9850.83%
Return on Capital Employed (ROCE)	-28.85%	-32.91%	-48.26%	-132.27%	-115.92%	-55.88%
Buyback Yield / Dilution	-29.57%	-36.21%	-581.85%	-104.57%	-28.20%	-23.19%
Total Shareholder Return	-29.57%	-36.21%	-581.85%	-104.57%	-28.20%	-23.19%

Updated May 5, 2026. Data Source: Fiscal.ai. Standard template. Financial Sources.

SEC Filings: 10-K · 10-Q