Spyre Therapeutics Stock Forecast

Stock Price Forecast

The 4 analysts that cover Spyre Therapeutics stock have a consensus rating of "Strong Buy" and an average price target of $55.75, which forecasts a 149.00% increase in the stock price over the next year. The lowest target is $43 and the highest is $70.

Price Target: $55.75 (+149.00%)

Analyst Consensus: Strong Buy

Target	Low	Average	Median	High
Price	$43	$55.75	$65	$70
Change	+92.05%	+149.00%	+190.31%	+212.64%

* Price targets were last updated on Sep 26, 2025.

Analyst Ratings

The average analyst rating for Spyre Therapeutics stock is "Strong Buy". This means that analysts believe this stock is likely to perform very well in the near future and significantly outperform the market.

Recommendation Trends

Rating	Jun '25	Jul '25	Aug '25	Sep '25	Oct '25	Nov '25
Strong Buy	2	2	2	3	3	2
Buy	5	5	5	2	2	2
Hold	1	1	1	1	1	1
Sell	0	0	0	0	0	0
Strong Sell	0	0	0	0	0	0
Total	8	8	8	6	6	5

Latest Forecasts

Analyst	Firm	Rating	Rating	Action	Price Target	Upside	Date
David Hoang Deutsche Bank	Deutsche Bank	Strong Buy Initiates $43	Strong Buy	Initiates	$43	+92.05%	Sep 26, 2025
Julian Harrison BTIG	BTIG	Strong Buy Reiterates $70	Strong Buy	Reiterates	$70	+212.64%	Sep 16, 2025
Faisal Khurshid Leerink Partners	Leerink Partners	Buy Initiates $45	Buy	Initiates	$45	+100.98%	Apr 8, 2025
Debanjana Chatterjee Jones Trading	Jones Trading	Hold Initiates n/a	Hold	Initiates	n/a	n/a	Dec 11, 2024
Colleen Kusy Baird	Baird	Buy Maintains $50 → $65	Buy	Maintains	$50 → $65	+190.31%	Nov 13, 2024

More Analyst Ratings

Financial Forecast

Revenue This Year

n/a

Revenue Next Year

n/a

EPS This Year

-2.85

from -3.18

EPS Next Year

-3.33

from -2.85

Fiscal Year	FY 2020	FY 2021	FY 2022	FY 2023	FY 2024	FY 2025	FY 2026
Period Ending	Dec 31, 2020	Dec 31, 2021	Dec 31, 2022	Dec 31, 2023	Dec 31, 2024	Dec 31, 2025	Dec 31, 2026
Revenue	-	18.74M	2.33M	886.00K	-	-	-
Revenue Growth	-	-	-87.57%	-61.96%	-	-	-
EPS	-37.89	-25.02	-24.86	-13.76	-3.18	-2.85	-3.33
EPS Growth	-	-	-	-	-	-	-
Forward PE	-	-	-	-	-	-	-
No. Analysts	-	-	-	-	-	14	14

Historical EPS numbers are GAAP, while forecasted numbers may be non-GAAP.

Revenue Forecast

Revenue	2025	2026
High	n/a	n/a
Avg	n/a	n/a
Low	n/a	n/a

Revenue Growth

Revenue Growth	2025	2026
High	-	-
Avg	-	-
Low	-	-

EPS Forecast

EPS	2025	2026
High	-2.42	-2.61
Avg	-2.85	-3.33
Low	-3.43	-4.12

EPS Growth

EPS Growth	2025	2026
High	-	-
Avg	-	-
Low	-	-

Sources: Price targets and analyst ratings provided by Benzinga. Revenue and EPS forecast data provided by Finnhub. The data is sourced from Wall Street analysts. Data disclaimer.