Spyre Therapeutics, Inc. (SYRE)
NASDAQ: SYRE · Real-Time Price · USD
16.26
+0.23 (1.47%)
Oct 8, 2025, 9:56 AM EDT - Market open
Spyre Therapeutics Analyst Ratings
Total Analysts
6
Consensus Rating
Strong Buy
Price Target
$57.60
Upside
+254.35%
Ratings History
| Analyst | Firm | Rating | Rating | Action | Price Target | Upside | Date |
|---|---|---|---|---|---|---|---|
| Deutsche Bank | Deutsche Bank | Strong Buy Initiates $43 | Strong Buy | Initiates | $43 | +164.53% | Sep 26, 2025 |
| BTIG | BTIG | Strong Buy Reiterates $70 | Strong Buy | Reiterates | $70 | +330.64% | Sep 16, 2025 |
| Leerink Partners | Leerink Partners | Buy Initiates $45 | Buy | Initiates | $45 | +176.84% | Apr 8, 2025 |
| Jones Trading | Jones Trading | Hold Initiates n/a | Hold | Initiates | n/a | n/a | Dec 11, 2024 |
| Baird | Baird | Buy Maintains $50 → $65 | Buy | Maintains | $50 → $65 | +299.88% | Nov 13, 2024 |
| Guggenheim | Guggenheim | Strong Buy Maintains $50 → $65 | Strong Buy | Maintains | $50 → $65 | +299.88% | Oct 25, 2024 |
| Wedbush | Wedbush | Buy Initiates $45 | Buy | Initiates | $45 | +176.84% | Sep 4, 2024 |
| Evercore ISI Group | Evercore ISI Group | Buy Initiates n/a | Buy | Initiates | n/a | n/a | Jul 16, 2024 |
| Wells Fargo | Wells Fargo | Buy Maintains $35 → $40 | Buy | Maintains | $35 → $40 | +146.08% | May 13, 2024 |
| BTIG | BTIG | Strong Buy Maintains $32 → $40 | Strong Buy | Maintains | $32 → $40 | +146.08% | May 10, 2024 |
| Baird | Baird | Buy Initiates $50 | Buy | Initiates | $50 | +207.60% | May 2, 2024 |
| Stifel | Stifel | Strong Buy Reiterates $36 → $54 | Strong Buy | Reiterates | $36 → $54 | +232.21% | Mar 26, 2024 |
| Wells Fargo | Wells Fargo | Hold → Buy Upgrades $12 → $35 | Hold → Buy | Upgrades | $12 → $35 | +115.32% | Mar 1, 2024 |
| BTIG | BTIG | Strong Buy Initiates $32 | Strong Buy | Initiates | $32 | +96.86% | Dec 20, 2023 |
| Stifel | Stifel | Strong Buy Maintains $23 → $27 | Strong Buy | Maintains | $23 → $27 | +66.10% | Dec 18, 2023 |
| Jefferies | Jefferies | Strong Buy Initiates $31 | Strong Buy | Initiates | $31 | +90.71% | Dec 11, 2023 |
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Analyst Star Rankings
Our analyst star rankings are based on these four factors
- Success Rate
- The percentage of ratings that are profitable.
- Average Return
- The average percentage return within one year of the rating.
- Rating Count
- The more ratings the analyst has provided, the higher the score.
- Recency
- Ratings provided within the past year contribute to a higher score.