Spyre Therapeutics, Inc. (SYRE)
NASDAQ: SYRE · Real-Time Price · USD
43.21
+5.40 (14.28%)
At close: Feb 20, 2026, 4:00 PM EST
43.34
+0.13 (0.30%)
After-hours: Feb 20, 2026, 7:40 PM EST
Spyre Therapeutics Analyst Ratings
Total Analysts
7
Consensus Rating
Strong Buy
Price Target
$55.57
Upside
+28.60%
Ratings History
| Analyst | Firm | Rating | Rating | Action | Price Target | Upside | Date |
|---|---|---|---|---|---|---|---|
| Wells Fargo | Wells Fargo | Buy Maintains $40 → $50 | Buy | Maintains | $40 → $50 | +15.71% | Feb 20, 2026 |
| BTIG | BTIG | Strong Buy Reiterates $70 | Strong Buy | Reiterates | $70 | +62.00% | Feb 20, 2026 |
| BTIG | BTIG | Strong Buy Reiterates $70 | Strong Buy | Reiterates | $70 | +62.00% | Jan 16, 2026 |
| Mizuho | Mizuho | Buy Initiates $53 | Buy | Initiates | $53 | +22.66% | Dec 18, 2025 |
| Citigroup | Citigroup | Strong Buy Initiates $64 | Strong Buy | Initiates | $64 | +48.11% | Dec 17, 2025 |
| Jones Trading | Jones Trading | Hold → Strong Buy Upgrades $64 | Hold → Strong Buy | Upgrades | $64 | +48.11% | Dec 1, 2025 |
| Deutsche Bank | Deutsche Bank | Strong Buy Initiates $43 | Strong Buy | Initiates | $43 | -0.49% | Sep 26, 2025 |
| BTIG | BTIG | Strong Buy Reiterates $70 | Strong Buy | Reiterates | $70 | +62.00% | Sep 16, 2025 |
| Leerink Partners | Leerink Partners | Buy Initiates $45 | Buy | Initiates | $45 | +4.14% | Apr 8, 2025 |
| Jones Trading | Jones Trading | Hold Initiates n/a | Hold | Initiates | n/a | n/a | Dec 11, 2024 |
| Baird | Baird | Buy Maintains $50 → $65 | Buy | Maintains | $50 → $65 | +50.43% | Nov 13, 2024 |
| Guggenheim | Guggenheim | Strong Buy Maintains $50 → $65 | Strong Buy | Maintains | $50 → $65 | +50.43% | Oct 25, 2024 |
| Wedbush | Wedbush | Buy Initiates $45 | Buy | Initiates | $45 | +4.14% | Sep 4, 2024 |
| Evercore ISI Group | Evercore ISI Group | Buy Initiates n/a | Buy | Initiates | n/a | n/a | Jul 16, 2024 |
| Wells Fargo | Wells Fargo | Buy Maintains $35 → $40 | Buy | Maintains | $35 → $40 | -7.43% | May 13, 2024 |
| BTIG | BTIG | Strong Buy Maintains $32 → $40 | Strong Buy | Maintains | $32 → $40 | -7.43% | May 10, 2024 |
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Analyst Star Rankings
Our analyst star rankings are based on these four factors
- Success Rate
- The percentage of ratings that are profitable.
- Average Return
- The average percentage return within one year of the rating.
- Rating Count
- The more ratings the analyst has provided, the higher the score.
- Recency
- Ratings provided within the past year contribute to a higher score.