Spyre Therapeutics, Inc. (SYRE)

Spyre Therapeutics Statistics

Total Valuation

SYRE has a market cap or net worth of $2.26 billion. The enterprise value is $1.78 billion.

Market Cap	2.26B
Enterprise Value	1.78B

Important Dates

The last earnings date was Tuesday, November 4, 2025, after market close.

Earnings Date	Nov 4, 2025
Ex-Dividend Date	n/a

Share Statistics

SYRE has 77.59 million shares outstanding. The number of shares has increased by 59.15% in one year.

Current Share Class	77.59M
Shares Outstanding	77.59M
Shares Change (YoY)	+59.15%
Shares Change (QoQ)	+0.13%
Owned by Insiders (%)	6.74%
Owned by Institutions (%)	78.13%
Float	67.56M

Valuation Ratios

PE Ratio	n/a
Forward PE	n/a
PS Ratio	n/a
Forward PS	n/a
PB Ratio	5.90
P/TBV Ratio	7.57
P/FCF Ratio	n/a
P/OCF Ratio	n/a
PEG Ratio	n/a

Enterprise Valuation

EV / Earnings	n/a
EV / Sales	n/a
EV / EBITDA	n/a
EV / EBIT	n/a
EV / FCF	n/a

Financial Position

The company has a current ratio of 10.90

Current Ratio	10.90
Quick Ratio	10.58
Debt / Equity	n/a
Debt / EBITDA	n/a
Debt / FCF	n/a
Interest Coverage	n/a

Financial Efficiency

Return on equity (ROE) is -38.08% and return on invested capital (ROIC) is -35.73%.

Return on Equity (ROE)	-38.08%
Return on Assets (ROA)	-30.20%
Return on Invested Capital (ROIC)	-35.73%
Return on Capital Employed (ROCE)	-48.80%
Revenue Per Employee	n/a
Profits Per Employee	-$1.82M
Employee Count	65
Asset Turnover	n/a
Inventory Turnover	n/a

Taxes

Income Tax	-14,000
Effective Tax Rate	n/a

Stock Price Statistics

The stock price has increased by +5.36% in the last 52 weeks. The beta is 3.17, so SYRE's price volatility has been higher than the market average.

Beta (5Y)	3.17
52-Week Price Change	+5.36%
50-Day Moving Average	20.94
200-Day Moving Average	17.56
Relative Strength Index (RSI)	75.36
Average Volume (20 Days)	650,169

Short Selling Information

The latest short interest is 12.41 million, so 15.99% of the outstanding shares have been sold short.

Short Interest	12.41M
Short Previous Month	13.39M
Short % of Shares Out	15.99%
Short % of Float	18.37%
Short Ratio (days to cover)	10.10

Income Statement

Revenue	n/a
Gross Profit	-177.50M
Operating Income	-223.64M
Pretax Income	-148.98M
Net Income	-118.38M
EBITDA	n/a
EBIT	-223.64M
Earnings Per Share (EPS)	-$2.00

Balance Sheet

The company has $486.20 million in cash and n/a in debt, giving a net cash position of $486.20 million or $6.27 per share.

Cash & Cash Equivalents	486.20M
Total Debt	n/a
Net Cash	486.20M
Net Cash Per Share	$6.27
Equity (Book Value)	455.10M
Book Value Per Share	4.95
Working Capital	458.33M

Cash Flow

Operating Cash Flow	-161.87M
Capital Expenditures	n/a
Free Cash Flow	-161.87M
FCF Per Share	-$2.09

Margins

Gross Margin	n/a
Operating Margin	n/a
Pretax Margin	n/a
Profit Margin	n/a
EBITDA Margin	n/a
EBIT Margin	n/a
FCF Margin	n/a

Dividends & Yields

SYRE does not appear to pay any dividends at this time.

Dividend Per Share	n/a
Dividend Yield	n/a
Dividend Growth (YoY)	n/a
Years of Dividend Growth	n/a
Payout Ratio	n/a
Buyback Yield	-59.15%
Shareholder Yield	-59.15%
Earnings Yield	-5.22%
FCF Yield	-7.14%

Analyst Forecast

The average price target for SYRE is $52.67, which is 80.47% higher than the current price. The consensus rating is "Strong Buy".

Price Target	$52.67
Price Target Difference	80.47%
Analyst Consensus	Strong Buy
Analyst Count	4
Revenue Growth Forecast (5Y)	n/a
EPS Growth Forecast (5Y)	-0.39%

Fair Value

There are several formulas that can be used to estimate the intrinsic value of a stock.

Lynch Fair Value	n/a
Lynch Upside	n/a
Graham Number	n/a
Graham Upside	n/a

Stock Splits

The last stock split was on September 8, 2023. It was a reverse split with a ratio of 1:25.

Last Split Date	Sep 8, 2023
Split Type	Reverse
Split Ratio	1:25

Scores

Altman Z-Score	n/a
Piotroski F-Score	1