Spyre Therapeutics, Inc. (SYRE)

NASDAQ: SYRE · Real-Time Price · USD

29.19

+2.22 (8.21%)

At close: Nov 25, 2025, 4:00 PM EST

29.20

+0.02 (0.05%)

After-hours: Nov 25, 2025, 5:57 PM EST

Spyre Therapeutics Ratios and Metrics

Market cap in millions USD. Fiscal year is January - December.

Millions USD. Fiscal year is Jan - Dec.

Fiscal Year	Current	FY 2024	FY 2023	FY 2022	FY 2021	FY 2020	2015 - 2019
Period Ending	Nov '25 Nov 25, 2025	Dec '24 Dec 31, 2024	Dec '23 Dec 31, 2023	Dec '22 Dec 31, 2022	Dec '21 Dec 31, 2021	Dec '20 Dec 31, 2020	2015 - 2019
Market Capitalization	2,265	1,367	775	28	234	377	Upgrade
Market Cap Growth	16.82%	76.31%	2701.10%	-88.19%	-37.90%	70.36%	Upgrade
Enterprise Value	1,779	1,108	959	-41	127	243	Upgrade
Last Close Price	29.20	23.28	21.52	11.25	118.75	196.75	Upgrade
PS Ratio	-	-	874.91	11.88	12.50	-	Upgrade
PB Ratio	5.90	2.64	4.21	0.55	2.79	2.70	Upgrade
P/TBV Ratio	7.57	3.78	-	0.55	2.79	2.70	Upgrade
EV/Sales Ratio	-	-	1082.03	-	6.78	-	Upgrade
Debt / Equity Ratio	-	-	-	0.09	0.07	0.04	Upgrade
Asset Turnover	-	-	0.00	0.03	0.14	-	Upgrade
Quick Ratio	10.59	11.16	10.61	3.83	4.66	8.90	Upgrade
Current Ratio	10.91	11.26	10.68	4.25	4.91	9.11	Upgrade
Return on Equity (ROE)	-38.08%	-59.28%	-289.17%	-124.87%	-58.81%	-80.93%	Upgrade
Return on Assets (ROA)	-30.20%	-27.43%	-35.60%	-58.53%	-30.22%	-41.61%	Upgrade
Return on Capital (ROIC)	-35.73%	-37.15%	-61.52%	-73.41%	-34.95%	-48.37%	Upgrade
Return on Capital Employed (ROCE)	-48.80%	-37.60%	-38.00%	-150.10%	-73.10%	-56.10%	Upgrade
Earnings Yield	-5.22%	-15.22%	-43.70%	-302.87%	-28.09%	-21.44%	Upgrade
FCF Yield	-7.14%	-11.52%	-12.89%	-289.74%	-23.17%	-21.22%	Upgrade
Buyback Yield / Dilution	-59.15%	-581.85%	-104.59%	-28.19%	-23.18%	-67.05%	Upgrade

Updated Sep 30, 2025. Source: S&P Global Market Intelligence. Standard template. Financial Sources.

SEC Filings: 10-K · 10-Q