Spyre Therapeutics, Inc. (SYRE)

NASDAQ: SYRE · Real-Time Price · USD

43.21

+5.40 (14.28%)

At close: Feb 20, 2026, 4:00 PM EST

43.34

+0.13 (0.30%)

After-hours: Feb 20, 2026, 7:40 PM EST

Spyre Therapeutics Ratios and Metrics

Market cap in millions USD. Fiscal year is January - December.

Millions USD. Fiscal year is Jan - Dec.

Fiscal Year	Current	FY 2025	FY 2024	FY 2023	FY 2022	FY 2021
Period Ending	Feb '26 Feb 20, 2026	Dec '25 Dec 31, 2025	Dec '24 Dec 31, 2024	Dec '23 Dec 31, 2023	Dec '22 Dec 31, 2022	Dec '21 Dec 31, 2021
Market Capitalization	3,394	2,542	1,367	775	28	234
Market Cap Growth	180.08%	85.99%	76.31%	2701.10%	-88.19%	-37.90%
Enterprise Value	2,637	2,212	1,108	959	-41	127
Last Close Price	43.21	32.76	23.28	21.52	11.25	118.75
PS Ratio	-	-	-	874.91	11.88	12.50
PB Ratio	6.04	3.55	2.64	4.21	0.55	2.79
P/TBV Ratio	6.07	4.54	3.78	-	0.55	2.79
EV/Sales Ratio	-	-	-	1082.03	-	6.78
Debt / Equity Ratio	-	-	-	-	0.09	0.07
Net Debt / Equity Ratio	-1.06	-1.06	-1.16	-1.84	-1.01	-1.04
Net Debt / EBITDA Ratio	-	-	2.90	2.90	0.61	1.37
Net Debt / FCF Ratio	4.47	4.47	3.83	3.40	0.64	1.62
Asset Turnover	-	-	-	0.00	0.03	0.14
Quick Ratio	12.94	12.94	11.16	10.61	3.83	4.66
Current Ratio	13.25	13.25	11.26	10.68	4.25	4.91
Return on Equity (ROE)	-25.17%	-25.17%	-59.28%	-289.17%	-124.87%	-58.81%
Return on Assets (ROA)	-19.80%	-19.80%	-27.43%	-35.60%	-58.53%	-30.22%
Return on Capital Employed (ROCE)	-30.50%	-30.50%	-37.60%	-38.00%	-150.10%	-73.10%
Earnings Yield	-3.73%	-6.11%	-15.22%	-43.70%	-302.87%	-28.09%
FCF Yield	-4.99%	-6.66%	-11.52%	-12.89%	-289.74%	-23.17%
Buyback Yield / Dilution	-36.21%	-36.21%	-581.85%	-104.59%	-28.19%	-23.18%

Updated Dec 31, 2025. Source: S&P Global Market Intelligence. Standard template. Financial Sources.

SEC Filings: 10-K · 10-Q