Upstream Bio, Inc. (UPB)

Upstream Bio Ratios and Metrics

Market cap in millions USD. Fiscal year is January - December.

Fiscal Year	Current	FY 2024	FY 2023
Period Ending	Oct 10, 2025	Dec 31, 2024	Dec 31, 2023
Market Cap	1,052	881	1,179
Market Cap Growth	-	-25.26%	-
Enterprise Value	674.85	411.92	1,303
Last Close Price	19.51	16.44	22.00
PE Ratio	-	-2.95	-1.70
PS Ratio	283.65	371.83	495.43
PB Ratio	2.60	1.88	-9.58
P/TBV Ratio	1.86	0.48	-0.53
P/FCF Ratio	-	-14.77	-30.97
P/OCF Ratio	-	-14.89	-31.09
EV/Sales Ratio	247.83	173.81	547.53
EV/EBITDA Ratio	-	-5.30	-32.53
EV/EBIT Ratio	-	-5.30	-32.49
EV/FCF Ratio	-	-6.90	-34.23
Debt / Equity Ratio	0.00	0.00	0.03
Debt / EBITDA Ratio	-0.01	-0.02	-0.07
Debt / FCF Ratio	-0.01	-0.03	-0.08
Asset Turnover	0.01	0.01	0.02
Quick Ratio	36.10	43.87	16.87
Current Ratio	38.27	44.63	17.96
Return on Equity (ROE)	-23.77%	-21.74%	-19.05%
Return on Assets (ROA)	-26.95%	-25.97%	-34.23%
Return on Capital (ROIC)	-1216.56%	-3719.88%	-4369.72%
Return on Capital Employed (ROCE)	-27.61%	-26.74%	-36.24%
Earnings Yield	-10.32%	-33.94%	-58.86%
FCF Yield	-10.74%	-6.77%	-3.23%
Buyback Yield / Dilution	-0.11%	-30.97%	-0.01%
Total Shareholder Return	-	-30.97%	-0.01%

Updated Aug 6, 2025. Data Source: Fiscal.ai. Standard template. Financial Sources.

SEC Filings: 10-K · 10-Q