Upstream Bio Ratios and Metrics

Market cap in millions USD. Fiscal year is January - December.

Millions USD. Fiscal year is Jan - Dec.

Fiscal Year	Current	FY 2025	FY 2024	FY 2023	FY 2022
Period Ending	Apr '26 Apr 16, 2026	Dec '25 Dec 31, 2025	Dec '24 Dec 31, 2024	Dec '23 Dec 31, 2023	Dec '22 Dec 31, 2022
Market Cap	533	1,467	881	-	-
Market Cap Growth	44.72%	66.49%	-	-	-
Enterprise Value	197.43	1,126	411.92	0	0
Last Close Price	9.80	27.15	16.44	-	-
PE Ratio	-	-10.21	-2.95	-	-
PS Ratio	188.39	514.07	371.83	-	-
PB Ratio	1.58	4.32	1.88	-	-
P/TBV Ratio	1.55	4.30	0.48	-	-
P/FCF Ratio	-	-10.99	-14.77	-	-
P/OCF Ratio	-	-11.01	-14.89	-	-
EV/Sales Ratio	69.18	394.60	173.81	-	-
EV/EBITDA Ratio	-	-7.03	-5.30	-	-
EV/EBIT Ratio	-	-7.02	-5.30	-	-
EV/FCF Ratio	-	-8.44	-6.90	-	-
Debt / Equity Ratio	0.00	0.00	0.00	0.01	0.00
Debt / EBITDA Ratio	-0.01	-0.01	-0.02	-0.07	0.00
Debt / FCF Ratio	-0.01	-0.01	-0.03	-0.08	0.00
Net Debt / Equity Ratio	-1.00	-1.00	-1.00	0.87	0.16
Net Debt / EBITDA Ratio	2.12	2.12	6.03	2.67	0.71
Net Debt / FCF Ratio	2.55	2.55	7.85	2.81	0.89
Asset Turnover	0.01	0.01	0.01	0.04	0.07
Quick Ratio	25.44	25.44	43.87	16.87	3.60
Current Ratio	26.15	26.15	44.63	17.96	3.77
Return on Equity (ROE)	-35.43%	-35.43%	-17.92%	-11.95%	-21.16%
Return on Assets (ROA)	-38.39%	-38.39%	-25.97%	-59.13%	-129.39%
Return on Invested Capital (ROIC)	-41869.70%	-41869.70%	-7223.78%	3309.74%	715.41%
Return on Capital Employed (ROCE)	-39.53%	-39.53%	-26.74%	-64.54%	-175.52%
Earnings Yield	-26.68%	-9.80%	-33.94%	-	-
FCF Yield	-24.82%	-9.10%	-6.77%	-	-
Buyback Yield / Dilution	-293.59%	-293.59%	-363.22%	-0.56%	-
Total Shareholder Return	-293.59%	-293.59%	-363.22%	-0.56%	-

Updated Dec 31, 2025. Data Source: Fiscal.ai. Standard template. Financial Sources.

SEC Filings: 10-K · 10-Q