Upstream Bio, Inc. (UPB)

NASDAQ: UPB · Real-Time Price · USD

2.780

-0.080 (-2.80%)

Nov 13, 2026, 4:00 PM EST - Market closed

Upstream Bio Cash Flow Statement

Financials in millions USD. Fiscal year is January - December.

Millions USD. Fiscal year is Jan - Dec.

Operating Activities

Fiscal Year	TTM	FY 2025	FY 2024	FY 2023	FY 2022
Period Ending	Sep '26 Sep 30, 2026	Dec '25 Dec 31, 2025	Dec '24 Dec 31, 2024	Dec '23 Dec 31, 2023	Dec '22 Dec 31, 2022
Net Income	-163.94	-143.44	-62.81	-20.54	-23.87
Depreciation & Amortization	0.21	0.19	0.09	0.06	0.01
Loss (Gain) From Sale of Investments	0.16	-1.5	-1.66	-1.26	-
Stock-Based Compensation	15.85	10.33	6	3.43	1.28
Other Operating Activities	0.61	0.56	-2.68	-15.31	0.15
Change in Accounts Receivable	0.29	-0.06	-0.52	0.31	-0.41
Change in Accounts Payable	-1.57	-1.28	2.02	1.28	0.46
Change in Other Net Operating Assets	-19.94	1.93	0.37	-5.9	3.36
Operating Cash Flow	-168.33	-133.28	-59.17	-37.93	-19.02
Operating Cash Flow Growth	-	-	-	-	-

Investing Activities

Fiscal Year	TTM	FY 2025	FY 2024	FY 2023	FY 2022
Period Ending	Sep '26 Sep 30, 2026	Dec '25 Dec 31, 2025	Dec '24 Dec 31, 2024	Dec '23 Dec 31, 2023	Dec '22 Dec 31, 2022
Capital Expenditures	-0.05	-0.17	-0.51	-0.14	-0.08
Investment in Securities	139.34	-93.32	-58.97	-82.7	-
Investing Cash Flow	139.28	-93.48	-59.49	-82.84	-0.08

Financing Activities

Fiscal Year	TTM	FY 2025	FY 2024	FY 2023	FY 2022
Period Ending	Sep '26 Sep 30, 2026	Dec '25 Dec 31, 2025	Dec '24 Dec 31, 2024	Dec '23 Dec 31, 2023	Dec '22 Dec 31, 2022
Issuance of Common Stock	4.3	2.48	272.88	0.12	-
Other Financing Activities	-	-0.03	-3.97	-	-0.04
Financing Cash Flow	4.3	2.44	418.91	129.55	9.96

Net Cash Flow

Fiscal Year	TTM	FY 2025	FY 2024	FY 2023	FY 2022
Period Ending	Sep '26 Sep 30, 2026	Dec '25 Dec 31, 2025	Dec '24 Dec 31, 2024	Dec '23 Dec 31, 2023	Dec '22 Dec 31, 2022
Net Cash Flow	-24.75	-224.31	300.25	8.78	-9.14

Free Cash Flow

Fiscal Year	TTM	FY 2025	FY 2024	FY 2023	FY 2022
Period Ending	Sep '26 Sep 30, 2026	Dec '25 Dec 31, 2025	Dec '24 Dec 31, 2024	Dec '23 Dec 31, 2023	Dec '22 Dec 31, 2022
Free Cash Flow	-168.39	-133.44	-59.68	-38.07	-19.1
Free Cash Flow Growth	-	-	-	-	-
Free Cash Flow Margin	-5867.18%	-4675.54%	-2518.27%	-1599.58%	-1576.15%
Free Cash Flow Per Share	-3.09	-2.48	-4.36	-12.89	-6.82
Levered Free Cash Flow	-114.34	-88.75	-40.98	-25.96	-
Unlevered Free Cash Flow	-114.34	-88.75	-40.98	-25.96	-

Additional Metrics

Fiscal Year	TTM	FY 2025	FY 2024	FY 2023	FY 2022
Period Ending	Sep '26 Sep 30, 2026	Dec '25 Dec 31, 2025	Dec '24 Dec 31, 2024	Dec '23 Dec 31, 2023	Dec '22 Dec 31, 2022
Change in Working Capital	-21.22	0.59	1.87	-4.31	3.41

SEC Filings: 10-K · 10-Q