Upstream Bio, Inc. (UPB)

Upstream Bio Statistics

Total Valuation

Upstream Bio has a market cap or net worth of $1.07 billion. The enterprise value is $674.85 million.

Market Cap	1.07B
Enterprise Value	674.85M

Important Dates

The next estimated earnings date is Thursday, November 6, 2025, before market open.

Earnings Date	Nov 6, 2025
Ex-Dividend Date	n/a

Share Statistics

Upstream Bio has 53.91 million shares outstanding. The number of shares has increased by 1,177.72% in one year.

Current Share Class	53.91M
Shares Outstanding	53.91M
Shares Change (YoY)	+1,177.72%
Shares Change (QoQ)	+0.29%
Owned by Insiders (%)	0.08%
Owned by Institutions (%)	63.44%
Float	31.42M

Valuation Ratios

PE Ratio	n/a
Forward PE	n/a
PS Ratio	283.65
Forward PS	492.45
PB Ratio	2.60
P/TBV Ratio	2.61
P/FCF Ratio	n/a
P/OCF Ratio	n/a
PEG Ratio	n/a

Enterprise Valuation

EV / Earnings	n/a
EV / Sales	247.83
EV / EBITDA	n/a
EV / EBIT	n/a
EV / FCF	n/a

Financial Position

The company has a current ratio of 38.27, with a Debt / Equity ratio of 0.00.

Current Ratio	38.27
Quick Ratio	36.25
Debt / Equity	0.00
Debt / EBITDA	n/a
Debt / FCF	n/a
Interest Coverage	n/a

Financial Efficiency

Return on equity (ROE) is -32.49% and return on invested capital (ROIC) is -23.58%.

Return on Equity (ROE)	-32.49%
Return on Assets (ROA)	-22.85%
Return on Invested Capital (ROIC)	-23.58%
Return on Capital Employed (ROCE)	-29.68%
Revenue Per Employee	$52,365
Profits Per Employee	-$2.12M
Employee Count	52
Asset Turnover	0.01
Inventory Turnover	n/a

Taxes

Income Tax	n/a
Effective Tax Rate	n/a

Stock Price Statistics

Beta (5Y)	n/a
52-Week Price Change	n/a
50-Day Moving Average	17.55
200-Day Moving Average	11.99
Relative Strength Index (RSI)	63.83
Average Volume (20 Days)	459,962

Short Selling Information

The latest short interest is 3.01 million, so 5.59% of the outstanding shares have been sold short.

Short Interest	3.01M
Short Previous Month	3.10M
Short % of Shares Out	5.59%
Short % of Float	9.59%
Short Ratio (days to cover)	5.81

Income Statement

In the last 12 months, Upstream Bio had revenue of $2.72 million and -$110.06 million in losses. Loss per share was -$2.82.

Revenue	2.72M
Gross Profit	2.72M
Operating Income	-121.57M
Pretax Income	-104.47M
Net Income	-110.06M
EBITDA	-121.42M
EBIT	-121.57M
Loss Per Share	-$2.82

Balance Sheet

The company has $393.58 million in cash and $1.56 million in debt, giving a net cash position of $392.02 million or $7.27 per share.

Cash & Cash Equivalents	393.58M
Total Debt	1.56M
Net Cash	392.02M
Net Cash Per Share	$7.27
Equity (Book Value)	408.74M
Book Value Per Share	7.60
Working Capital	407.34M

Cash Flow

In the last 12 months, operating cash flow was -$113.98 million and capital expenditures -$558,000, giving a free cash flow of -$114.54 million.

Operating Cash Flow	-113.98M
Capital Expenditures	-558,000
Free Cash Flow	-114.54M
FCF Per Share	-$2.12

Margins

Gross Margin	100.00%
Operating Margin	-4,464.60%
Pretax Margin	-3,836.58%
Profit Margin	n/a
EBITDA Margin	n/a
EBIT Margin	n/a
FCF Margin	n/a

Dividends & Yields

Upstream Bio does not appear to pay any dividends at this time.

Dividend Per Share	n/a
Dividend Yield	n/a
Dividend Growth (YoY)	n/a
Years of Dividend Growth	n/a
Payout Ratio	n/a
Buyback Yield	-1,177.72%
Shareholder Yield	-1,177.72%
Earnings Yield	-10.32%
FCF Yield	-10.74%

Analyst Forecast

The average price target for Upstream Bio is $56.50, which is 185.50% higher than the current price. The consensus rating is "Strong Buy".

Price Target	$56.50
Price Target Difference	185.50%
Analyst Consensus	Strong Buy
Analyst Count	4
Revenue Growth Forecast (5Y)	n/a
EPS Growth Forecast (5Y)	n/a

Fair Value

There are several formulas that can be used to estimate the intrinsic value of a stock.

Lynch Fair Value	n/a
Lynch Upside	n/a
Graham Number	n/a
Graham Upside	n/a

Stock Splits

This stock does not have any record of stock splits.

Last Split Date	n/a
Split Type	n/a
Split Ratio	n/a

Scores

Upstream Bio has an Altman Z-Score of 31.6 and a Piotroski F-Score of 1.

Altman Z-Score	31.6
Piotroski F-Score	1